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16-Aug-2017 16:04

Possible explanations for sex differences in the incidence of adolescent MDD include: girls having more negative thinking styles, ruminating on interpersonal and body image events, having greater hormone fluctuations, reporting more negative events and sexual abuse, a higher vulnerability to inflammation (2), and estrogen-induced stress response enhancement of the prefrontal cortex (3).

The genetic risk for MDD also differs strikingly between sexes with more heritability in women (4).

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The incidence of MDD for girls rises from age 11 to 13 years until by age 15 one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males (although this predominance might disappear after age 55 years) (1).In response to sad relative to neutral distractors, significant sex differences (in the supramarginal gyrus) and group-by-sex interactions (in the supramarginal gyrus and the posterior cingulate cortex) were found.

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Preserved leaves in the cores — “they look fresh as if they’ve fallen very recently”, Bronk Ramsey says — yielded 651 carbon dates that could be compared to the calendar dates of the sediment they were found in.… continue reading »

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